Nutritional Biochemistry
Long-form mechanistic write-ups — evidence graded, conflicts of interest disclosed, contrary findings engaged rather than smoothed over. Not medical advice.
What metabolic health actually is, what breaks it, and the order in which to fix it — the framework and protocol that the mechanism deep-dives below plug into. Opens with a short, shareable list of easy changes.
Read the paper →Oxidative mechanisms linking excess seed-oil linoleic acid to cardiovascular disease, insulin resistance, obesity, and cancer risk. A plain-language primer on fat chemistry, evidence graded throughout, and a full answer to the strongest counterargument.
Read the paper →Concedes that apoB is causal, then argues the harder point: that a population-level cause makes a poor individual-level target. Absolute vs relative risk, the mevalonate pathway beyond cholesterol, and the harms sorted honestly — diabetes yes, muscle pain mostly not.
Read the paper →How one transcription factor links gut permeability, tryptophan metabolism, seed-oil oxidation, hyperinsulinaemia, and B-vitamin status to the circadian collapse of NAD⁺.
Read the paper →The acute, insulin-independent glucose-disposal effect and the adaptive, batokine-mediated systemic effect — plus the thermogenic, mood, and immune effects that build on them.
Read the paper →Sunlight is eight overlapping exposures, not one — the same UVB band that mutates skin-cell DNA also drives the vitamin D and immune pathways ecologically linked to lower rates of over a dozen other cancers. Worked through band by band, then against three human studies on melanoma survival, all-cause mortality, and cancer incidence.
Read the paper →How mitochondrial dysfunction may drive the cancer cell’s signature behaviours — and why treating it as primarily a genetic disease has stalled progress for two decades. Drawing on Seyfried’s metabolic model with evidence graded throughout.
Read the paper →How glucose, fat, and protein all funnel into acetyl-CoA and the Krebs cycle, told through flow diagrams — and the small set of B-vitamin coenzymes (TPP, FAD, NAD⁺, CoA, PLP, biotin) that run the whole system. Background for everything above.
Read the primer →The nutrient-level detail that Metabolic Health deliberately keeps out: mechanism, deficiency effects, intake, food sources, and citations where they exist, one page per nutrient.
Browse the index →Herbs and isolated compounds evaluated one at a time for whether they earn a place at all — evidence graded, with practical notes on form, dose, and sourcing. Beet Juice, Black Seed, Chinese Skullcap, Citrus Peel, Mastic Gum, Molecular Hydrogen, Orange Juice, and Pomegranate.
Browse the index →Every substantive claim carries an inline grade — Strong, Moderate, Animal/in-vitro, Inferred, Contested, or Speculative — attached to that specific claim rather than a whole section.
Where a synthesis originates from advocacy sources rather than a study demonstrating it end-to-end, that is stated at point of use, with mainstream reviews cited alongside.
Each paper states the strongest case against its own thesis at full strength before answering it — and says plainly where the reply is weak.
A plain-language primer comes first, and enzyme-level detail is quarantined into optional blocks with a takeaway that carries the essential point.
A follow-up on ferroptosis and iron-driven oxidative stress is currently being scoped.